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💉 Ozempic, Mounjaro, retatrutide… the headlines keep getting bigger. But what’s behind the weight-loss numbers, and what should you know beyond the before-and-after photos?
🔍 In this video, Dr. Michael Diamonds breaks down semaglutide, tirzepatide, and retatrutide in plain English—exploring how they work, the research behind them, and the trade-offs that deserve more attention.
💪 From appetite and side effects to the difference between losing weight and losing fat, there’s more to this conversation than which injection delivers the biggest drop on the scale.
👇 *What’s your biggest question about weight-loss medication: results, side effects, or keeping the weight off? Let me know in the comments!*
*Watch until the end for the question that matters beyond the transformation: what happens when the injections stop—and where do daily habits fit into the bigger picture?*
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The information presented in this video is for educational purposes only. Dr. Mike Diamonds does not claim to diagnose, treat, cure, or prevent any disease. All health-related improvements shown or mentioned are based on individual experiences and should not be interpreted as typical or guaranteed outcomes. Always consult with a qualified healthcare professional before making changes to your diet, exercise routine, or medical treatment.
Any transformations presented in this video represent exceptional results. The average male client who starts with 17%+ body fat and completes our program loses 24lbs during their first 16 weeks. The average female client who starts with 17%+ body fat and completes our program loses 17.5lbs during their first 16 weeks. Results vary based on starting weight, commitment level, and individual circumstances. Individual results may be higher or lower than average.
Changes in health markers, such as blood pressure, blood sugar levels, cholesterol, testosterone levels, and resting heart rate, vary from person to person. These metrics are influenced by factors including genetics, nutrition, exercise adherence, sleep, and stress management.
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Why are you not mentioning the dosage or timing?
How would this effect people with low metabolism through diseases they have for example
Which do you think is better: Retatrutide or Tirzepatide?
I am 171 pounds with 27% of body fat and considering Reta with test prop, high protien diet, 4 – 5 times heavy weight resistance training in a week and 20 mins steady state cardio to come below 15% body fat only.
Another doctor Mike?
Doc you DEFINITELY focused on the negative here, unfairly I think. Most of the sides you talked about with the higher percentage is because the dose is too high…. They were testing the limits, the minimum dosages had Wayyyyy lower sides and almost the same gains!! So let's be honest, your channel is focused on non drug solutions, which is great! But your slant here is clear sorry…. I do appreciate you for sure. And the focus on the $$ was just silky, may have these covered with insurance or partially, or they get them in the gray and they have GREAT results as well. People are going to do what they do. And your 3rd fucus on muscle is EASILY mitigated by eating 1lb of protein per target body weight plus strength training 2-3x a week…. Easy to preserve muscle, some gain muscle while doing this. If you go for lowest effective dose you will be fine. Don't get all the negative spin when there are tons of positive things like liver and gut fat, and all the benefits of less fat gets you. I feel like Glp1 just don't fit with your paradigm so your spinning it negatively instead of seeing the positives…. But doc, like it or not, they ARe the future, better figure how to roll with it somewhat
Reta is king, gym 3 times a week lost 24 pounds in 3 months, stopped using it haven't gained any weight, but stayed on high protein low carb diet
Be very careful on sourcing and dosages… I lost 50 pounds in 5 months and it caused kidney damage… very effective but also very dangerous.. make sure you are running monthly labs.. especially on kidney function
Reta is awesome
Hi, I am 35, 5’1 156 pounds. I have been strength training for a while and lost weight before but also looked skinny fat i believe I did too much cardio. I gained weight again but have some muscle and would like to cut now. I strength train 4 to 5 days a week and I try to aim for 10,000 steps per day since I have an office job. For a cut would I add more steps or should I add cardio sessions in there? I do the step machine as cardio sometimes but only for about 10 min and realistically only once a week. For macros would I calculate using moderate activity level? And would a 40,40,20 macro split work best? Do I eat the same amount of calories macros on rest day? Do I recalculate calories as the weight goes down? Sorry for all the questions but I want to get it right this time 🙂
It’s about the habits that you implement whilst using this tool to aid your weight loss. Keep up the habits once you stop the GLP1 and this will minimise the weight you are told you will put back on.
Keep the weights ups, eating habits low carb high protein, good sleep etc this will aid you as you have kept a lot of the muscle that you would have lost if you didn’t do this. Metabolic health through diet and aided by the muscle you kept will be a massive boost to keeping that weight off.
5 months on Reta, lost 15 vanity pounds at a microdose (500 mcg to start, never over 1.5 mg/week). Lift heavy 4x/week. Amazing molecule, no nausea, or other gut issues but…had to quit as it really messed up my sleep. Maintenance on low dose Triz.
I wonder why nobody makes these videos about blood pressure and cholesterol medicines
there you go Doctor another video about RETA, i appreciate it. I've been on RETA for about 5 months, I'm disgusted with food as soon as i start eating. Started off slow dose but I'm now in the upper dose level. I prioritize musle with supplements. only lost 8% so far. the dial did start moving on the higher does. None of the side effects you mentioned.
Not sure if you’ve come across Nora Renwick before, but she has a book called The Deficit Method that might interest you. It focuses on understanding weight loss and building a more realistic approach rather than just following strict rules.
My wife has been using one of these and lost a significant amount of weight; however, she has kept that loose belly skin. I know the body can eventually process that excess skin, but is there a way to work on it and speed it up?
The shots and pills are just artificial willpower. It's always better to learn how to cook, what foods to cook, and what combinations. And you're set up for life and it's a lot less expensive.
Reta should be taken by almost everyone no matter how fat you are
Reta alongside Resistance train it’s that simple 🤷🏾!!!!
None of these drugs cause muscle loss. Any organism on planet earth that stops eating will lose muscle, its a survival mechanism to keep you alive. Muscle loss occurs during every single calorie deficit, unless you give your body a signal to hold on to muscle. Resistance training is required to maintain muscle in a calorie deficit plus eating enough protein.
If you abuse these compounds and want to put absolutely zero effort into your body then yes you will lose muscle.
Accountability
For one thing this is not a weight drug thats actually a bonus .. it corrects functioning of the heart kidneys liver lungs and brain.. also treats inflammation also all by lower your body weight .. while killing your cravings and food noise. People whos weight comes back are dur to a few thing 1 they didn't down trait from high doses to micro or they didn't allow the positive benefits lead them to making healthier lifestyles changes .. ive been on for close to a year n lost 50lbs no alcohol sugar or bad eating cravings they are all gone the want for chips n sweets are 100% gone .. my labs are all A++ results.. ive had good labs before but this is A1 .. clear mind clean energy all day everyday.. i micro dose .5 ml for longevity benefits.. i haven't even had a cold lol and yes i strength train 5 to 6 days a week with cardio its a must… highly recommend 👌🏾
I know several people, personally, taking Reta. One's tastes changed. Coffee, that she loves, tasted horrible, and her meats started doing the same. This went on for a little better than a month, but when the food or liquids felt like they were up to her throat and started belching a lot, she quit. Been off almost 2 weeks and already reporting improvement. I, also, heard that people who are prone to cardiac arrhythmias should be cautious because it can, actually, throw them into a-fib, if they're prone to it. I, personally, like that it does help with improving heart health, but it's not true for everyone. I am a fan of the GLP-1s, but if you don't have medical knowledge and able to monitor yourself, then you need a reliable practitioner to guide you. Also, people have got to make it a priority to eat protein first and resistant train. Thanks for your intake on GLP-1s.
I don't have a more trusted health channel than this one. After watching here for a while I found Your Body Wants to Heal by Dr. Sarah Kline and it filled in every gap I still had. If you watch this channel, read that book — it completes the picture.
This video sucks
Everyone on YouTube makes the same mistake. Lean body mass on a dexa scan isn't just muscle. It's everything that's not fat. They didn't lose 15lbs of muscle. They are eating less, so there's less food in their system… shows as lean body mass. These drugs are anti-inflammatory and eating less reduces glycogen and water in the body…all of which show as lean body mass. I'm guessing half of that 15 lbs isn't actually muscle. The half that is can be mitigate easily by focusing on protein, strength training, and keeping the dose lower so the weightloss is slower. Scaring people away from these life changing drugs, especially the morbidly obese, by misinterpreting the data is flat dangerous.
This researches dont show how it would be in combination with weight training. DOes it also leads to loose of lean mass? I dont think so.
Serious question not being a smart ass. 33% experience this, 29% experience that, 15% experience that. Not saying they are not telling the truth. Not saying it's safe. How is it 1,000's of people from bodybuilders, fitness folks, regular Joe's are taking reta with minimal to no sides? Like TRT they mention all the side effects. What about the damage low T does? Increase heart risk, depression, low libido, etc. High blood pressure is possible dont take it. 😂
I love these types of videos, helpful and informational. Keep the good work doc mike 🔥
No I choose to follow a healthy weight loss program and keep muscles
Amen and thank you our heavenly father
Amen indeed
I CHOOSE MUSCLE AND LONGEVITY TO ANY DRUG NON NEGOTIABLE THANK YOU, YOU GOAT!❤🎉
Should we even trust Eli Lilly after Prozac scandals or promoting olanzapine? This company isn't interested in nation's health, only in making money.
Very good information
Or…you could just fast
Dr mike your videos changed my body,i am 13 years old and 20 pounds overweight,and your videos helped me a lot especially being a malaysian so i just wanted to say thank you,and quick question ever since i got the belly off i have been struggling to be consistent with my strength training do you have any tips for me(motivation and discipline related)