This clip is from episode #337 – Insulin resistance masterclass: The full body impact of metabolic dysfunction and prevention, diagnosis, and treatment with Ralph DeFronzo, M.D.
In this clip, they discuss:
– Are there any concerns with the current generation of GLP-1s other than the economic aspects that come with them?
– The fascinating world of GLP-1 drugs and their profound impact on weight loss, muscle mass, and insulin sensitivity.
– The potential risks and benefits, the science behind muscle preservation, and the exciting advancements in the pipeline.
——–
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The Peter Attia Drive is a deep-dive podcast focusing on maximizing longevity, and all that goes into that from physical to cognitive to emotional health. With over 90 million episodes downloaded, it features topics including exercise, nutritional biochemistry, cardiovascular disease, Alzheimer’s disease, cancer, mental health, and much more.
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So…..did he have any concerns?
DeFronzo's lean mass con hit me till I front loaded protein. Buy from Aureus Research LLC. COA each batch.
sux bc all these videos are paid for, they made it seem like they were going to talk about the truth! such bullsht! i want to know the real side effects years down the line. but not from someone making money off it!
I would rather be fat and disgusting than to make the CEOs, and all of these "doctor death fauci's of the world" more rich.
Most comments here are biased. Think of the long term effects in your gut, heart, muscle, hair etc…
Heart rate increase
10 years from now..
"Have you experienced severe and uncontrollable weight loss, muscle loss, psychiatrist issues or cancer from using GLPs? You may be entitled to compensation. Call pur law firm today "
Drugs ???? What Types???? 😳😳🧐🧐🤔
Great information
😮😮
I called this bs
Those people lose muscle mass because they don’t eat to sufficient protein
They rather continue eating the crap that are used to be eating
Am glad GLP 1 is helping people . But what happens when they stop taking the medication will they but weight back on . What about people going blind taking this medication that is scary stuff
The pros-and-cons framing is important because GLP-1s aren’t just “weight loss drugs.” They change appetite signaling, gastric emptying, insulin response and overall energy intake, so both the benefits and tradeoffs make more sense when you look at the physiology behind them.
It's making people blind come on
ordering from Evolve Peptides has been so uneventful that i can actually focus on stuff like this video instead of worrying about what i even got
Ive Been on reta for over a year now that i got from Evolve and its honestly been such a life saver, lost 55lbs as of today and its helped me quit alcohol and sugar. Genuenly a life changer
Of course you loe muscle mass. If you are heavyily obese, you will have leg muscles the size of tree trunks to carry that weight. When you lose weight, you will also lose leg muscles as their is no longer any need to carry 150 kg.
word
word
Besides weight loss has the retatrutide that i picked upp from Evolve peptides helped my quit drinking by just not making me have an urge for it and same with suger it has also improved my sleep SOOO much
We may not know the long term effects of glp1s (kinda) but we do know the long term effects of obesity and diabetes.
My mother in law is obsessed with the drugs, she can name a peptide for every sickness or pain. She somehow has vendors for all these drugs.
GLP-1
Interesting.
Wait, what, stomach paralysis? That’s not a good thing. And I bet nobody knows what the stats are on that time will tell.
Great, now post the three ways. Don’t tell us you’ll post then not post.
I’ve seen a review stating that once you stop taking it, you will regain your weight, is that true?
So what do GLP 1s do for you if you’re already calorie tracking and being disciplined?
oh boy, skinny people can't stand it when fat people find an easier way to lose weight, they really believe they somehow earned being thin when the truth is their bodies don't require work to be that way, you can tell them this but they won't believe you because they believe every word that comes from a fat mouth is disgusting just like they believe all fat people are evil disgusting lazy drains on them, they can't admit they didn't really have to work to be thin, maybe they worked hard to be athletic, but the truth is thin people are just thin, all of the hype that all of theassholes that comment 'just exercise and don't eat" is a lie, deep down some of them know it, most are too shallow and too unintelligent to understand
Focus on protein and lifting weights while on a Glp1
But don’t you lose muscle mass with age naturally anyway even without using a glp1 or losing weight 🤷🏽♂️
Peter
Long term data is still not available. How come you're not talking about the permanently stalled digestive tract? The death and near death cases. The emaciated people?
30 year olds should not need a drug to get in shape
I guess I’m in the minority, but I am 49, post-menopausal, and was around 5-7, 160, when I really recognized that the 25-ish pounds I had put on throughout perimenopause, etc., had to go. I was faced with high blood pressure and high cholesterol within months of each other, and I just felt sluggish and low confidence. I decided to turn my life around “naturally”— because I knew, for me, that a GLP-1 wasn’t going to serve me well for the long haul. And I didn’t want yet another chemical/prescription inside my body on top of the new BP med and statin! So, I cut out crappy foods; went low carb and low sugar, but also realistic and in moderation. Essentially I went Mediterranean. And I was stunned at how I loved my new foods. I began to naturally fast from 6p-11a, only allowing a 7-hour window for food consumption. Focused on protein and fiber. Started weight training and daily air squats. Walking. That was 7 months ago, and I am now 5-7, 130. I have toned arms and legs. Love wearing my tank tops! I feel amazing; it’s like I can literally sense and feel the absence of inflammation inside my body! I just want to encourage people that you CAN do it without a GLP-1! You CAN have a new lifestyle— not just a diet that you hate— but rather a new lovely lifestyle that is happy and exciting. And also, you CAN eat birthday cake and Christmas goodies and yummy things on vacation! — the motto should be for your life: “Consistency in maintenance, flexibility for life”… that’s how you maintain— by doing something realistic. Look, here’s the thing: Weight loss isn’t easy, but it’s simple.
From what I read the GLP1 ate hormones we make in our intestines. So why not from the beginning using a time released pill dircted at the gut, instead of injecting it to rhighs arms and outside the belly. Or is it the highly processed American corp food chemicals that block the humam gut from making GLP1?
what is the average life expectance for Medical Doctors in USA in the past 50+ years?
I lift and run and play soccer regularly with tirzepatide and I’m completely fine. People just over restrict and want to rush the result to save money and see quick losses. Do it right and safely and it will be a life changer. Food noise was so loud for me before I took it
What about increased risk of thoracic cancers?
Tried the lowest dose of ozempic for 3 weeks. I have never felt so sick, nauseated and tired. I felt like a shell of myself. Not for me I guess…
25% strength loss is only a little bit to him?! But I get his point.
You can also lose bone—becoming osteopenic or osteoporotic.
thanks for sharing
Is there someone who has really used these injections helped me know the truth behind it ?
I did intermediate fasting and in 1 months I lost 30 pounds and quiet bit of my strength too.
Really informative discussion. I appreciate that they talked about both the benefits and the concerns around GLP-1s instead of treating them like a miracle solution. The focus on muscle preservation, insulin sensitivity, and long-term metabolic health is so important.
I’ve also found that combining healthy habits with supportive wellness products like FormBlends can make the journey feel more sustainable overall, especially when focusing on energy, appetite support, and consistency alongside medical treatment.
Im on Mounjaro lost about 60 pounds my doctor tolm just lift weights dont even walk, so i did that and just mainly body fat.
Is post-drug satiety regulation worse than pre-drug satiety regulation at the same body weight?
the "not cheating" argument lands harder when you realize the people most resistant to it are usually the ones who've never struggled with actual metabolic dysfunction. easy to moralize from outside that experience.
been on compounded sema through formblends at a conservative dose and the results are boring in the best way possible. no drama, just works.
what Dr. Mike is basically arguing here is that tool use doesnt define cheating, context does. and that framing actually applies to dosing strategy too, because the instinct to just ramp to max and declare victory isnt always the smartest play.
i've been on compounded sema for a while now, went through formblends, and my provider genuinely never pressured me to chase the ceiling. stayed lower than most people i talk to and the appetite suppression was still meaningful. slower progress, way fewer rough days.
the "good thing we have pills to help us" line at the end is the whole point tbh